New Mechanism That Regulates the Formation of Skin Discovered

New Mechanism That Regulates the Formation of Skin Discovered

The published work shows that Fra-2, a transcription factor, plays a key regulatory role in epidermis formation.

“With the help of specific mouse models we demonstrate that the expression of Fra-2 in keratinocytes induces the expression of genes in the Epidermal Differentiation Complex (EDC)” the authors write.

Conversely, loss of Fra-2 in suprabasal keratinocytes was sufficient to cause skin barrier defects, due to reduced expression of EDC genes

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