In a double-blind study, a commercially available physiological lipid mixture (containing ceramide 3) was found to promote barrier recovery in SLS-irritated and tape-stripped human skin, compared with the untreated control area. However, the barrier recovery was not superior to its placebo (petrolatum) (Figure 15.2).
Ingredients of Locobase Repair: Petrolatum, Aqua, Paraffin, Paraffinum Liquidum, Glycerin, Sorbitan Oleate, Carnauba, Cholesterol, Ceramide 3, Oleic Acid, Palmitic Acid, Carbomer, Tromethamine
I’d like to see a comparison between the Locobase product that more directly compares the lipid mixture vs. petrolatum. Perhaps a setup with the Locobase vs. an emulsion with the same water to petrolatum proportions would work.
The published work shows that Fra-2, a transcription factor, plays a key regulatory role in epidermis formation.
“With the help of specific mouse models we demonstrate that the expression of Fra-2 in keratinocytes induces the expression of genes in the Epidermal Differentiation Complex (EDC)” the authors write.
Conversely, loss of Fra-2 in suprabasal keratinocytes was sufficient to cause skin barrier defects, due to reduced expression of EDC genes
Using a microscopy technique researchers were able to “watch” what happened to a comedone a week after it was removed.
Previous research has shown that comedones have a cyclical nature, either forming into inflammatory acne, re-appearing, or resolving.
Based on clinical experience, this cycle was estimated to take between 2-6 weeks. However, no studies had been done that provided direct evidence for this timeline.
A week after the comedone was extracted the skin appeared to resolve – to the naked eye. Under a microscope, however, researchers found that dead skin cells and sebum were already beginning to accumulate and reform the comedone.
This highlights the importance of continuing acne treatment even after the skin looks like it has cleared. This may also provide evidence for the use of acne treatments over the entire face or affected area instead of spot treating.
Further research with this technique could show how acne treatments prevent this comedone reformation, if there is individual variation on this reformation, what changes in the skin cells is causing the excess build up, and how long a lesion needs to be treated before the pore returns to normal.
Dr. Rajani Katta, professor of dermatology at Baylor, recommends showering with lukewarm water for no more than 10 to 15 minutes during wintery months.
“Very dry skin, if not reversed, can progress to skin inflammation and eczema, which calls for a different course of treatment,” she added.
Signs of skin inflammation are: redness, itching, scaling, and cracking.